产品货号：
Z12439
中文名称：
Caspase 1/CASP1 (p10)抗体
英文名称：
Anti-Caspase 1/CASP1 (p10) Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Caspase 1/CASP1 (p10) Antibody |
| 指标别名 | CASP 1;CASP1;Caspase 1;Caspase 1/p20/p10;Caspase1;ICE;IL 1 beta converting enzyme;IL 1BC;IL1BC;IL1BCE;p10;p20;P45 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | CASP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-1(P10)(249-262aa VFIGRLIEHMQEYA). |
| 实际分子量 | 45KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Caspase 1,apoptosis-related cysteine protease,is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta,IL18,and IL33 precursor proteins.Caspase 1 was purified ICE from the cytosol of the THP.human monocytic cell line and found that the active protease was made up of 2 peptides,which they called p20 and p10 based on their apparent molecular masses by SDS-PAGE.It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue.The Caspase1 gene consists of 10 exons spanning at least 10.6kb.The Caspase 1 gene is mapped to 11q23,a site frequently involved in rearrangement in human cancers,including a number of leukemias and lymphomas,by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes.Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. |
| Uniprot ID | P29466 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | caspase 1,apoptosis-related cysteine peptidase |
| 蛋白名全称 | Caspase-1(CASP-1) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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